Week 4 of the 2025 NFL season is packed with compelling matchups and betting opportunities, and online sportsbooks are offering competitive odds for every game this weekend.
One of the most anticipated games features the undefeated Philadelphia Eagles visiting the Tampa Bay Buccaneers, with Bovada listing the Eagles as slight favorites. Later in the day, two MVP-caliber quarterbacks, Patrick Mahomes and Lamar Jackson, go head-to-head as the Chiefs host the Ravens.
Sunday Night Football brings added drama with the Cowboys facing the Packers. Micah Parsons returns to Dallas in a new uniform, and 18+ online sportsbooks currently favor Green Bay by a touchdown. Across the board, most Week 4 spreads are tight, with 10 games featuring lines of seven points or fewer.
Game Line Odds For Week 4
Philadelphia Eagles vs. Tampa Bay Buccaneers
- Spread: Eagles -3.5 (-110), Buccaneers +3.5 (-110)
- Win: Eagles -185, Buccaneers +160
- Total: Over 44.0 (-110), Under 44.0 (-110)
Baltimore Ravens vs. Kansas City Chiefs
- Spread: Ravens -2.5 (-115), Chiefs +2.5 (-105)
- Win: Ravens -145, Chiefs +125
- Total: Over 48.0 (-110), Under 48.0 (-110)
Seattle Seahawks vs. Arizona Cardinals
- Spread: Seahawks -1.5 (-115), Cardinals +1.5 (-105)
- Win: Seahawks -130, Cardinals +110
- Total: Over 43.5 (-105), Under 43.5 (-115)
Los Angeles Chargers vs. New York Giants
- Spread: Chargers -6.0 (-115), Giants +6.0 (-105)
- Win: Chargers -290, Giants +240
- Total: Over 44.0 (-110), Under 44.0 (-110)
Jacksonville Jaguars vs. San Francisco 49ers
- Spread: Jaguars +3.0 (EVEN), 49ers -3.0 (-120)
- Win: Jaguars +150, 49ers -175
- Total: Over 47.0 (-110), Under 47.0 (-110)
New Orleans Saints vs. Buffalo Bills
- Spread: Saints +16.0 (-110), Bills -16.0 (-110)
- Win: Saints +775, Bills -1500
- Total: Over 48.0 (-105), Under 48.0 (-115)
Green Bay Packers vs. Dallas Cowboys
- Spread: Packers -7.0 (-105), Cowboys +7.0 (-115)
- Win: Packers -340, Cowboys +270
- Total: Over 47.0 (-115), Under 47.0 (-105)
More odds at Bovada
How To Make Smart NFL Bets
Making smart NFL bets involves a strategic blend of research, discipline, and informed decision-making.
First, it’s essential to understand the types of wagers available. Moneyline bets focus on picking the outright winner, point spreads involve predicting the margin of victory, and totals (or over/under) bets center on the combined score of both teams.
Successful bettors dive deep into matchup analysis, reviewing team statistics, injury reports, weather conditions, and historical trends to gain an edge.
Note: Shopping for the best lines across sportsbooks like Bovada, BetUS, or MyBookie can also improve value, as even slight differences in odds can impact your total payout.
Equally important is bankroll management: setting a budget, avoiding emotional decisions, and sticking to consistent bet sizes helps minimize risk. Tracking your bets and reviewing outcomes allows you to refine your strategy over time. Incorporating advanced metrics, such as DVOA or EPA, can offer deeper insights into team performance.
Ultimately, intelligent betting is about making calculated choices based on data, not emotions or attachments, and staying disciplined throughout the season.
